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Sobi is providing this free tool to help you find healthcare providers in your area who may have experience treating chronic ITP. Neither Sobi nor MediFind pay healthcare providers to be listed in this tool and healthcare providers do not pay to be listed in the tool. Just because a healthcare provider is listed in the tool does not mean Sobi endorses their qualifications or recommends their medical care. The search results of healthcare providers are sorted by the distance from the location entered. Choosing a healthcare provider is an important decision requiring careful consideration. Sobi is not responsible for your choice or actions you take because of information provided by the tool.
ABOUT PERSISTENT & CHRONIC ITP
Understanding your child’s ITP diagnosis is important. Learn about the causes of this rare platelet disorder in children and explore potential treatment approaches.
What are the common signs and symptoms of ITP?
ITP is known as a heterogeneous disease, which means your child may experience different signs and symptoms than someone else with ITP.
A sign is something that your child’s healthcare team can observe or measure, such as their platelet counts. Symptoms are the feelings and concerns that your child experiences, such as fatigue. Most people with ITP have platelet counts under 100,000 per microliter, but those counts vary from person to person, and your child may find their platelet counts are unpredictable at times. The lower their platelet count, the greater the risk of ITP symptoms.
Here are some common signs and symptoms of ITP:
Fatigue
Your child may feel exhausted and unable to keep up with everyday activities to the point where they may feel tired even after getting a full night’s sleep.
Bruising
Your child may notice their skin start to bruise very easily, even spontaneously, from damaged blood vessels under the skin. Bruising may happen even if they don’t remember injuring themselves.
Petechiae/Purpura
Your child may see small red or purple spots start to appear from broken blood vessels on areas like their upper arms or lower legs.
ITP Bleeding
Your child may experience bleeding from their gums and nose, have an unusually heavy menstrual flow, or notice cuts bleeding for longer periods of time. They may also see blood in their urine, vomit, or stool.
These are not all the signs and symptoms of ITP. It is important to discuss your signs and symptoms with your doctor as only a doctor can diagnose ITP. Doptelet and Doptelet Sprinkle are not approved to treat these symptoms.
How is persistent and chronic ITP treated in children?
There are a few options for treating persistent and chronic ITP, such as corticosteroids, intravenous immunoglobulin (IVIG), rituximab, and TPO-RAs that offer different benefits and risks. Click on each of these common treatment options to learn how they work.
Corticosteroids are immunosuppressants that can work by reducing inflammation and the overall activity of your child’s immune system. For ITP, they are commonly prescribed right after diagnosis and are intended for short-term use to stop the body from destroying platelets.
While steroids can be effective, continued use, especially at high doses, may have side effects such as increased weight gain, swelling of the face, sleep problems, and mood disturbances such as irritability. Steroids may also come with increased risk of infections, diabetes, cataracts, liver issues, high blood pressure, high blood sugar, osteoporosis, and bone and muscle disorders.
For these reasons, the experts who wrote the current American Society of Hematology (ASH) ITP guidelines recommend limiting steroid treatment to less than 6 weeks.
Ask your child’s doctor for more information about the ASH Guidelines.
IVIG is an immune-modulating therapy made of antibodies that can help regulate your child’s immune system. IVIG is a first-line treatment typically used in emergency, short-term situations when platelet counts are severely low. IVIG can work by reducing certain immune responses that may be responsible for destroying platelets, but unlike immunosuppressants, it does not weaken the entire immune system.
Rituximab is an immunosuppressant. Like steroids, it can work to reduce the overall activity of your child’s immune system to stop their body from destroying platelets. Because rituximab changes how the immune system works, it may be easier for your child to get sick or develop other conditions.
Talk to your child’s doctor about what treatment may be right for them. If other therapies aren’t working for your child and their platelet counts don’t stay lifted, their doctor may consider a thrombopoietin receptor agonist (TPO-RA), such as Doptelet or Doptelet Sprinkle.
Treating with Doptelet and Doptelet Sprinkle, medicines called TPO-RAs
Doptelet and Doptelet Sprinkle are TPO-RAs, which are a type of medication that mimics the body’s natural process of creating platelets. Doptelet and Doptelet Sprinkle can help boost the pathway responsible for making platelets, which adds to the platelets your child’s body is already making. This ultimately can increase their overall count. Doptelet tablets and Doptelet Sprinkle are not used to make platelet counts normal.
Neither Doptelet nor Doptelet Sprinkle requires weekly doctor’s appointments for treatment injections or becomes less effective when your child eats certain foods, like ice cream. Doptelet as a tablet must be taken with food. Doptelet Sprinkle oral granules must be mixed with a soft food or liquid like applesauce or orange juice. See the Instructions for Use for a full list of recommended soft foods and liquids. Work with the doctor to determine a dosing schedule that works best for you and your child. The doctor may also adjust their dose based on other medications your child takes and their platelet counts.
Your child’s doctor will check their platelet count before, during, and for at least 4 weeks after stopping their treatment with Doptelet or Doptelet Sprinkle.
Find a persistent or chronic ITP specialist near you
One of the most important steps to getting the care your child deserves is finding the right provider in your area.
Find a specialistSobi is not responsible for the choices or actions that you or others take because of information provided by this free tool.
Indication & Important Safety Information
What are DOPTELET (avatrombopag) and DOPTELET Sprinkle (avatrombopag)?
DOPTELET is a prescription medicine used to treat low blood platelet counts in:
- Adults with long-lasting (chronic) liver disease (CLD) who are scheduled to have a medical or dental procedure
- Adults with chronic immune thrombocytopenia (ITP) when other treatments have not worked well enough.
- Children 1 year and older with persistent or chronic ITP when other treatments have not worked well enough
DOPTELET tablets and DOPTELET Sprinkle are different dosage forms of DOPTELET.
DOPTELET and DOPTELET Sprinkle are not used to make platelet counts normal.
It is not known if DOPTELET or DOPTELET Sprinkle are safe and effective in children younger than 1 year of age.
IMPORTANT SAFETY INFORMATION
Before you take DOPTELET or DOPTELET Sprinkle, tell your doctor about all your medical conditions, including if you:
- Have ever had a blood clot
- Are pregnant or plan to become pregnant. DOPTELET or DOPTELET Sprinkle may harm your unborn baby. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with DOPTELET or DOPTELET Sprinkle
- Are breastfeeding or plan to breastfeed. It is not known if DOPTELET or DOPTELET Sprinkle passes into your breast milk. Do not breastfeed during your treatment with DOPTELET and DOPTELET Sprinkle for at least 2 weeks after the last dose. Talk to your healthcare provider about the best way to feed your baby during this time
Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. DOPTELET or DOPTELET Sprinkle may affect the way other medicines work, and other medicines may affect the way DOPTELET or DOPTELET Sprinkle works.
What are the side effects of DOPTELET or DOPTELET Sprinkle?
DOPTELET or DOPTELET Sprinkle may cause serious side effects including blood clots. People with CLD or persistent or chronic ITP and people with certain blood clotting conditions may have an increased risk of developing blood clots. Tell your healthcare provider right away if you get signs and symptoms of a blood clot, including:
- Swelling, pain, or tenderness in your legs
- Shortness of breath
- Chest pain
- Fast heartbeat
- Stomach (abdominal) pain or tenderness
The most common side effects of DOPTELET in adults with CLD are fever, stomach (abdominal) pain, nausea, headache, tiredness, and swelling of hands and feet.
The most common side effects of DOPTELET in adults with chronic ITP are headache, tiredness, bruising, nosebleed, upper respiratory infection, joint pain, bleeding gums, purple or red spots on your skin, and runny nose.
The most common side effects of DOPTELET or DOPTELET Sprinkle in children with persistent or chronic ITP are viral infection, runny nose, cough, fever, and pain in the mouth or throat.
These are not all of the possible side effects of DOPTELET or DOPTELET Sprinkle. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Please see the DOPTELET and DOPTELET Sprinkle full Prescribing Information.
What are DOPTELET (avatrombopag) and DOPTELET Sprinkle (avatrombopag)?
DOPTELET is a prescription medicine used to treat low blood platelet counts in:
- Adults with long-lasting (chronic) liver disease (CLD) who are scheduled to have a medical or dental procedure
- Adults with chronic immune thrombocytopenia (ITP) when other treatments have not worked well enough.
- Children 1 year and older with persistent or chronic ITP when other treatments have not worked well enough
What are DOPTELET (avatrombopag) and DOPTELET Sprinkle (avatrombopag)?
DOPTELET is a prescription medicine used to treat low blood platelet counts in:
- Adults with long-lasting (chronic) liver disease (CLD) who are scheduled to have a medical or dental procedure
- Adults with chronic immune thrombocytopenia (ITP) when other treatments have not worked well enough.
- Children 1 year and older with persistent or chronic ITP when other treatments have not worked well enough
DOPTELET tablets and DOPTELET Sprinkle are different dosage forms of DOPTELET.
DOPTELET and DOPTELET Sprinkle are not used to make platelet counts normal.
It is not known if DOPTELET or DOPTELET Sprinkle are safe and effective in children younger than 1 year of age.
IMPORTANT SAFETY INFORMATION
Before you take DOPTELET or DOPTELET Sprinkle, tell your doctor about all your medical conditions, including if you:
- Have ever had a blood clot
- Are pregnant or plan to become pregnant. DOPTELET or DOPTELET Sprinkle may harm your unborn baby. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with DOPTELET or DOPTELET Sprinkle
- Are breastfeeding or plan to breastfeed. It is not known if DOPTELET or DOPTELET Sprinkle passes into your breast milk. Do not breastfeed during your treatment with DOPTELET and DOPTELET Sprinkle for at least 2 weeks after the last dose. Talk to your healthcare provider about the best way to feed your baby during this time
Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. DOPTELET or DOPTELET Sprinkle may affect the way other medicines work, and other medicines may affect the way DOPTELET or DOPTELET Sprinkle works.
What are the side effects of DOPTELET or DOPTELET Sprinkle?
DOPTELET or DOPTELET Sprinkle may cause serious side effects including blood clots. People with CLD or persistent or chronic ITP and people with certain blood clotting conditions may have an increased risk of developing blood clots. Tell your healthcare provider right away if you get signs and symptoms of a blood clot, including:
- Swelling, pain, or tenderness in your legs
- Shortness of breath
- Chest pain
- Fast heartbeat
- Stomach (abdominal) pain or tenderness
The most common side effects of DOPTELET in adults with CLD are fever, stomach (abdominal) pain, nausea, headache, tiredness, and swelling of hands and feet.
The most common side effects of DOPTELET in adults with chronic ITP are headache, tiredness, bruising, nosebleed, upper respiratory infection, joint pain, bleeding gums, purple or red spots on your skin, and runny nose.
The most common side effects of DOPTELET or DOPTELET Sprinkle in children with persistent or chronic ITP are viral infection, runny nose, cough, fever, and pain in the mouth or throat.
These are not all of the possible side effects of DOPTELET or DOPTELET Sprinkle. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Please see the DOPTELET and DOPTELET Sprinkle full Prescribing Information.
