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TAKING DOPTELET (AVATROMBOPAG) OR DOPTELET SPRINKLE (AVATROMBOPAG): A Caregiver’s Guide
Doptelet and Doptelet Sprinkle are once-a-day oral medications that help raise your child’s platelet counts without compromising some of their personal preferences. That means no needles for treatment injections and less time spent for extra doctor visits. Plus, the type of food doesn’t change how treatment works. Doptelet and Doptelet Sprinkle are not used to make platelet counts normal.
How to prepare and administer treatment
Doptelet or Doptelet Sprinkle can work with your child’s schedule
Doptelet is a 20-mg tablet that is taken with food. Doptelet Sprinkle is a 10-mg capsule containing oral granules that are mixed into, and taken with, soft food or liquid. Based on how your child's platelet count responds, their doctor will decide how much medicine they need to take and for how long. The doctor will also check your child's platelet count before, during, and for at least 4 weeks after stopping treatment. Doptelet Sprinkle oral granules that come in a bottle are not the same dosage form as Doptelet tablets that come in a blister card and cannot be directly substituted for each other.
Doptelet Sprinkle
Oral granules that must be sprinkled on a soft food or liquid.
Here are the steps to prepare and give a dose of Doptelet Sprinkle:
- Gather supplies: capsule(s), liquid or soft food, cup or spoon, and mixing utensil (eg, stir stick or small spoon); then wash your hands
Put a small amount of soft food or liquid in a cup or spoon. The following soft foods and liquids can be used:
Soft foods
- applesauce
- strawberry jelly
- yogurt (plain)
Liquids
- milk (whole or skim)
- orange juice
- pediatric electrolyte solution (unflavored)
- water
Carefully open the capsule (or 2 capsules if prescribed) by pulling it apart
- Sprinkle the entire contents of the capsule onto the soft food or liquid that you put in the spoon or cup. Make sure that all of the granules from the capsule have been completely emptied
- Mix or stir the granules into the soft food or liquid. The granules will not dissolve
- Give the mixture right away; do not save for later use
- Rinse the spoon or cup with additional soft food or liquid to make sure that the entire dose is given
- Throw the empty capsule shells away in the trash
Do not swallow the capsule whole or the empty capsule shells. Do not chew or crush the granules.
Doptelet and Doptelet Sprinkle may be affected by other drugs and may require a dose adjustment when coadministered with other drugs. Tell your child’s doctor about other prescription or nonprescription medications or dietary supplements. If your child is taking CYP2C9 and CYP3A4 inhibitors such as certain antibiotics, antifungals, or antiepileptic drugs, their doctor will start them on 20 mg of Doptelet tablet or 10 mg of Doptelet Sprinkle 3 times a week. If they are taking CYP2C9 and CYP3A4 inducers such as antibiotics, antifungals, or antiepileptic drugs, they will start on 40 mg of Doptelet tablet or 20 mg of Doptelet Sprinkle once a day. Please see the full Prescribing Information for more information on dose adjustments a doctor may make.
Is your child starting Doptelet or Doptelet Sprinkle?
Read more about what to expect when taking treatment for persistent or chronic ITP.
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Indication & Important Safety Information
What are DOPTELET (avatrombopag) and DOPTELET Sprinkle (avatrombopag)?
DOPTELET is a prescription medicine used to treat low blood platelet counts in:
- Adults with long-lasting (chronic) liver disease (CLD) who are scheduled to have a medical or dental procedure
- Adults with chronic immune thrombocytopenia (ITP) when other treatments have not worked well enough.
- Children 1 year and older with persistent or chronic ITP when other treatments have not worked well enough
DOPTELET tablets and DOPTELET Sprinkle are different dosage forms of DOPTELET.
DOPTELET and DOPTELET Sprinkle are not used to make platelet counts normal.
It is not known if DOPTELET or DOPTELET Sprinkle are safe and effective in children younger than 1 year of age.
IMPORTANT SAFETY INFORMATION
Before you take DOPTELET or DOPTELET Sprinkle, tell your doctor about all your medical conditions, including if you:
- Have ever had a blood clot
- Are pregnant or plan to become pregnant. DOPTELET or DOPTELET Sprinkle may harm your unborn baby. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with DOPTELET or DOPTELET Sprinkle
- Are breastfeeding or plan to breastfeed. It is not known if DOPTELET or DOPTELET Sprinkle passes into your breast milk. Do not breastfeed during your treatment with DOPTELET and DOPTELET Sprinkle for at least 2 weeks after the last dose. Talk to your healthcare provider about the best way to feed your baby during this time
Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. DOPTELET or DOPTELET Sprinkle may affect the way other medicines work, and other medicines may affect the way DOPTELET or DOPTELET Sprinkle works.
What are the side effects of DOPTELET or DOPTELET Sprinkle?
DOPTELET or DOPTELET Sprinkle may cause serious side effects including blood clots. People with CLD or persistent or chronic ITP and people with certain blood clotting conditions may have an increased risk of developing blood clots. Tell your healthcare provider right away if you get signs and symptoms of a blood clot, including:
- Swelling, pain, or tenderness in your legs
- Shortness of breath
- Chest pain
- Fast heartbeat
- Stomach (abdominal) pain or tenderness
The most common side effects of DOPTELET in adults with CLD are fever, stomach (abdominal) pain, nausea, headache, tiredness, and swelling of hands and feet.
The most common side effects of DOPTELET in adults with chronic ITP are headache, tiredness, bruising, nosebleed, upper respiratory infection, joint pain, bleeding gums, purple or red spots on your skin, and runny nose.
The most common side effects of DOPTELET or DOPTELET Sprinkle in children with persistent or chronic ITP are viral infection, runny nose, cough, fever, and pain in the mouth or throat.
These are not all of the possible side effects of DOPTELET or DOPTELET Sprinkle. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Please see the DOPTELET and DOPTELET Sprinkle full Prescribing Information.
What are DOPTELET (avatrombopag) and DOPTELET Sprinkle (avatrombopag)?
DOPTELET is a prescription medicine used to treat low blood platelet counts in:
- Adults with long-lasting (chronic) liver disease (CLD) who are scheduled to have a medical or dental procedure
- Adults with chronic immune thrombocytopenia (ITP) when other treatments have not worked well enough.
- Children 1 year and older with persistent or chronic ITP when other treatments have not worked well enough
What are DOPTELET (avatrombopag) and DOPTELET Sprinkle (avatrombopag)?
DOPTELET is a prescription medicine used to treat low blood platelet counts in:
- Adults with long-lasting (chronic) liver disease (CLD) who are scheduled to have a medical or dental procedure
- Adults with chronic immune thrombocytopenia (ITP) when other treatments have not worked well enough.
- Children 1 year and older with persistent or chronic ITP when other treatments have not worked well enough
DOPTELET tablets and DOPTELET Sprinkle are different dosage forms of DOPTELET.
DOPTELET and DOPTELET Sprinkle are not used to make platelet counts normal.
It is not known if DOPTELET or DOPTELET Sprinkle are safe and effective in children younger than 1 year of age.
IMPORTANT SAFETY INFORMATION
Before you take DOPTELET or DOPTELET Sprinkle, tell your doctor about all your medical conditions, including if you:
- Have ever had a blood clot
- Are pregnant or plan to become pregnant. DOPTELET or DOPTELET Sprinkle may harm your unborn baby. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with DOPTELET or DOPTELET Sprinkle
- Are breastfeeding or plan to breastfeed. It is not known if DOPTELET or DOPTELET Sprinkle passes into your breast milk. Do not breastfeed during your treatment with DOPTELET and DOPTELET Sprinkle for at least 2 weeks after the last dose. Talk to your healthcare provider about the best way to feed your baby during this time
Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. DOPTELET or DOPTELET Sprinkle may affect the way other medicines work, and other medicines may affect the way DOPTELET or DOPTELET Sprinkle works.
What are the side effects of DOPTELET or DOPTELET Sprinkle?
DOPTELET or DOPTELET Sprinkle may cause serious side effects including blood clots. People with CLD or persistent or chronic ITP and people with certain blood clotting conditions may have an increased risk of developing blood clots. Tell your healthcare provider right away if you get signs and symptoms of a blood clot, including:
- Swelling, pain, or tenderness in your legs
- Shortness of breath
- Chest pain
- Fast heartbeat
- Stomach (abdominal) pain or tenderness
The most common side effects of DOPTELET in adults with CLD are fever, stomach (abdominal) pain, nausea, headache, tiredness, and swelling of hands and feet.
The most common side effects of DOPTELET in adults with chronic ITP are headache, tiredness, bruising, nosebleed, upper respiratory infection, joint pain, bleeding gums, purple or red spots on your skin, and runny nose.
The most common side effects of DOPTELET or DOPTELET Sprinkle in children with persistent or chronic ITP are viral infection, runny nose, cough, fever, and pain in the mouth or throat.
These are not all of the possible side effects of DOPTELET or DOPTELET Sprinkle. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Please see the DOPTELET and DOPTELET Sprinkle full Prescribing Information.
