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Chronic ITP
What it is and how it’s treated.
What is “ITP”?
Having immune thrombocytopenia (ITP) means there’s a shortage of platelets in your blood. When you have ITP, it means your platelet count needs a lift. If you’ve had low platelet counts for over a year, you may have what’s called long-term or “chronic” ITP.
How is ITP treated?
Steroids are usually the first step in ITP prescriptions, but they can have unwanted side effects.
Doptelet is not a steroid—it is a TPO-RA (thrombopoietin receptor agonist) that can lift your platelet count. The best part? Unlike other oral TPO-RA treatments, you can choose your dosing schedule, and take it with any kind of food, no matter where you are. Before taking Doptelet, tell your doctor about your medical conditions, including if you’ve ever had a blood clot, are pregnant or plan to be. #FoodRequired
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Your body has a natural signal that tells it to make enough platelets for you; it’s a hormone called “thrombopoietin” or TPO.
When the signal from your TPO isn’t strong enough to make the number of platelets you need, Doptelet acts alongside your natural TPO. It sends a strong signal that tells your body to lift your platelet count and keep it lifted.
Platelets are the part of the blood that helps stop and prevent bleeding.
Yes, ITP is an autoimmune condition. If you have ITP, it means your own immune system is attacking the platelets in your body, leaving your platelet counts low. Having a low platelet count can increase the risk of bleeding or bruising. Sometimes ITP causes other symptoms like fatigue or purpura, a condition where red or purple spots appear on the skin.
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GET STARTEDWhat is DOPTELET® (avatrombopag) [dop-TELL-it]?
DOPTELET is a prescription medicine used to treat low blood platelet counts in adults with chronic immune thrombocytopenia (ITP) when other treatments have not worked well enough.
DOPTELET is not used to make platelet counts normal in adults with chronic immune thrombocytopenia. It is not known if DOPTELET is safe and effective in children.
Before you take DOPTELET, tell your healthcare provider about all of your medical conditions, including if you:
- have ever had a blood clot.
- are pregnant or plan to become pregnant. DOPTELET may harm your unborn baby. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with DOPTELET.
- are breastfeeding or plan to breastfeed. It is not known if DOPTELET passes into your breast milk. Do not breastfeed during your treatment with DOPTELET and for at least 2 weeks after the last dose. Talk to your healthcare provider about the best way to feed your baby during this time.
Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. DOPTELET may affect the way other medicines work, and other medicines may affect the way DOPTELET works.
How should I take DOPTELET?
- Take DOPTELET exactly as your healthcare provider tells you to take it.
- Your healthcare provider will tell you how much DOPTELET to take and when to start taking it.
- Your healthcare provider may change your dose of DOPTELET depending on your blood platelet counts.
- Take DOPTELET with food.
- If you take DOPTELET to treat your low blood platelet counts due to chronic immune thrombocytopenia, your healthcare provider will check your platelet count before, during and for at least 4 weeks after stopping your treatment with DOPTELET.
- If you are taking DOPTELET for chronic immune thrombocytopenia and you miss a dose of DOPTELET, take it as soon as you remember. Do not take 2 doses at one time to make up for a missed dose. Take your next dose at your usual scheduled time.
- If you take too much DOPTELET, call your healthcare provider or go to the nearest hospital emergency room right away.
What are the possible side effects of DOPTELET?
DOPTELET may cause serious side effects, including blood clots. People with chronic immune thrombocytopenia and people with certain blood clotting conditions may have an increased risk of developing blood clots. Tell your healthcare provider right away if you have signs and symptoms of a blood clot, including:
- swelling, pain, or tenderness in your legs
- shortness of breath
- chest pain
- fast heartbeat
- stomach (abdominal) pain or tenderness
The most common side effects of DOPTELET when used to treat low blood platelet counts in adults with chronic immune thrombocytopenia (ITP) are:
- headache
- tiredness
- bruising
- nosebleed
- upper respiratory tract infection
- joint pain
- bleeding gums
- purple or red spots on your skin
- runny nose
These are not all the possible side effects of DOPTELET.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How should I store DOPTELET?
- Store DOPTELET at room temperature between 68°F to 77°F (20°C to 25°C).
- Store DOPTELET tablets in the original package.
Keep DOPTELET and all medicines out of the reach of children.
General information about the safe and effective use of DOPTELET.
Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use DOPTELET for a condition for which it was not prescribed. Do not give DOPTELET to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about DOPTELET that is written for health professionals.
What are the ingredients in DOPTELET?
Active ingredient: avatrombopag
Inactive ingredients: lactose monohydrate, colloidal silicon dioxide, crospovidone, magnesium stearate and microcrystalline cellulose. Tablet coating film: polyvinyl alcohol, talc, polyethylene glycol, titanium dioxide and ferric oxide yellow.
Please see full Prescribing Information, including the Patient Information Leaflet.
This Patient Information has been approved by the U.S. Food and Drug Administration.
What is DOPTELET® (avatrombopag) [dop-TELL-it]?
DOPTELET is a prescription medicine used to treat low blood platelet counts in adults with chronic immune thrombocytopenia (ITP) when other treatments have not worked well enough.
DOPTELET is not used to make platelet counts normal in adults with chronic immune thrombocytopenia. It is not known if DOPTELET is safe and effective in children.
